{"id":1843,"date":"2025-07-02T08:27:45","date_gmt":"2025-07-02T08:27:45","guid":{"rendered":"https:\/\/chemikalstore.com\/?post_type=product&p=1843"},"modified":"2026-04-18T06:35:22","modified_gmt":"2026-04-18T06:35:22","slug":"4-2-methylpropoxybenzenemethanamine-hydrochloride","status":"publish","type":"product","link":"https:\/\/chemikalstore.com\/index.php\/product\/4-2-methylpropoxybenzenemethanamine-hydrochloride\/","title":{"rendered":"4-(2-Methylpropoxy)benzenemethanamine Hydrochloride"},"content":{"rendered":"

Buy 44-(2-Methylpropoxy)benzenemethanamine Hydrochloride Online \u2013 High-Purity Pharmaceutical Intermediate at chemikalstore.com<\/strong><\/h1>\n

4-2-methylpropoxybenzo methanamine hydrochloride (CAS 37806-44-3) is a specialty amine salt and a critical intermediate in the high technology of pharmaceutical, chemical and research. With chemikalstore.com, shopping on the internet, you are guaranteed to receive a high-purity compound that is well documented, can be traced back to batches and is delivered in no more than a few days, nationwide. This manual offers a full technical and commercial profile, search engine optimized on all of the main keywords and focused on industrial, laboratory, and research and development purchasers.<\/p>\n

What is 4-(2-Methylpropoxy)benzenemethanamine Hydrochloride?<\/strong><\/h2>\n

4- (2-Methylpropoxy) benzene methylanamine hydrochloride is an off-white crystalline solid. It is a hydrochloride salt of 4 -(2-methylpropoxy)benzenemethanamine, which comprises a benzylamine core with the para substituted by 2-methylpropoxy. This structure gives it lipophilicity and reactivity, which has been useful in the synthesis of pharmaceuticals particularly in the production of pimavanserin, an antipsychotic drug.<\/p>\n

Key Chemical and Physical Properties<\/strong><\/h2>\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Property<\/strong><\/th>\nSpecification<\/strong><\/th>\n<\/tr>\n<\/thead>\n
Appearance<\/td>\nWhite to off-white crystalline solid<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% (HPLC\/GC)<\/td>\n<\/tr>\n
Molecular Formula<\/td>\nC\u2081\u2081H\u2081\u2087NO\u00b7HCl<\/td>\n<\/tr>\n
Molecular Weight<\/td>\n215.72 g\/mol<\/td>\n<\/tr>\n
Melting Point<\/td>\n170\u2013175\u00b0C (typical, varies by batch)<\/td>\n<\/tr>\n
Solubility<\/td>\nSoluble in water, DMSO, methanol<\/td>\n<\/tr>\n
pH (1% solution)<\/td>\nNeutral to slightly basic<\/td>\n<\/tr>\n
Storage Temp<\/td>\n2\u20138\u00b0C, tightly sealed, dry place<\/td>\n<\/tr>\n
Packaging<\/td>\n1g, 5g, 10g, 25g, 100g, 500g, 1kg bottles<\/td>\n<\/tr>\n
Documentation<\/td>\nCOA, MSDS, HPLC\/NMR reports<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
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Applications of 4-(2-Methylpropoxy)benzenemethanamine Hydrochloride<\/strong><\/h2>\n

1. Pharmaceutical Intermediate<\/strong><\/h2>\n
    \n
  • \n

    Pimavanserin Synthesis:<\/strong> Pimavanserin is one of the major intermediates of the synthesis of pimavanserin, a type of antipsychotic medicine, which is used in treating the psychosis of Parkinson and schizophrenic disease.<\/p>\n<\/li>\n

  • \n

    Other CNS Drugs:<\/strong> Applied in the neuropsychiatric disorder analog research and development.<\/p>\n<\/li>\n<\/ul>\n

    2. Medicinal Chemistry and Drug Discovery<\/strong><\/h2>\n
      \n
    • \n

      Lead Optimization:<\/strong> The 2-methylpropoxy (isobutoxy) functional group has been used as a popular CNS-penetrating\/metabolic-stabilizing moiety.<\/p>\n<\/li>\n

    • \n

      SAR Studies:<\/strong> SAR Studies are used in structure-activity relationship (SAR) studies of new psychoactive and neuroactive drugs.<\/p>\n<\/li>\n<\/ul>\n

      3. Chemical Synthesis and Research<\/strong><\/h2>\n
        \n
      • \n

        Building Block:<\/strong> Applied in the production of substituted benzylamine, aryl ethers as well as heterocyclic scaffolds.<\/p>\n<\/li>\n

      • \n

        Reference Standard:<\/strong> Method development analytical standard of pharmaceutical QC Labs.<\/p>\n<\/li>\n<\/ul>\n

        Synthetic and Reaction Chemistry<\/strong><\/h2>\n

        Typical Synthetic Route<\/strong><\/h2>\n
          \n
        1. \n

          Etherification:<\/strong> 4-hydroxybenzylamine is alkylated with 2-methylpropyl bromide or tosylate to produce 4 ( 2 -methylpropoxy)benzylamine.<\/p>\n<\/li>\n

        2. \n

          Salt Formation:<\/strong> The free amine is transformed into the hydrochloride salt by either the bubbling of the HCl gas or with the use of aqueous HCl.<\/p>\n<\/li>\n<\/ol>\n

          Reactivity<\/strong><\/h2>\n
            \n
          • \n

            Nucleophilic Substitution:<\/strong> The benzylamine functional group is reactive to acylation, alkylation, and reduction amino.<\/p>\n<\/li>\n

          • \n

            Salt Stability:<\/strong> The hydrochloride is more stable than the amine and it is easier to work with and purify.<\/p>\n<\/li>\n<\/ul>\n

            Technical Specifications and Quality Control<\/strong><\/h2>\n
            \n
            \n\n\n\n\n\n\n\n\n\n\n\n
            Parameter<\/strong><\/th>\nSpecification<\/strong><\/th>\nTest Method<\/strong><\/th>\n<\/tr>\n<\/thead>\n
            Purity<\/td>\n\u226598%<\/td>\nHPLC\/GC<\/td>\n<\/tr>\n
            Water Content<\/td>\n\u22640.5%<\/td>\nKarl Fischer<\/td>\n<\/tr>\n
            Residual Solvents<\/td>\n\u22640.5%<\/td>\nGC-HS<\/td>\n<\/tr>\n
            Heavy Metals<\/td>\n\u226410 ppm<\/td>\nICP-OES<\/td>\n<\/tr>\n
            Identity (NMR\/IR)<\/td>\nConforms<\/td>\n\u00b9H\/\u00b9\u00b3C NMR, FTIR<\/td>\n<\/tr>\n
            Appearance<\/td>\nWhite\/off-white solid<\/td>\nVisual<\/td>\n<\/tr>\n
            Melting Point<\/td>\n170\u2013175\u00b0C<\/td>\nCapillary method<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
            \n
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            \n
            <\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

            Safety, Handling, and Storage<\/strong><\/h2>\n

            Hazard Classification<\/strong><\/h2>\n
              \n
            • \n

              GHS:<\/strong>\u00a0Not classified as hazardous under most regulations, but handle as a laboratory chemical<\/p>\n<\/li>\n

            • \n

              Precautions:<\/strong>\u00a0Avoid inhalation, ingestion, and contact with skin or eyes.<\/p>\n<\/li>\n

            • \n

              PPE:<\/strong>\u00a0Wear gloves, goggles, lab coat, and use in a fume hood.<\/p>\n<\/li>\n<\/ul>\n

              First Aid<\/strong><\/h2>\n
                \n
              • \n

                Inhalation:<\/strong>\u00a0Move to fresh air, seek medical attention if symptoms persist.<\/p>\n<\/li>\n

              • \n

                Skin Contact:<\/strong>\u00a0Wash with soap and water for 15 minutes.<\/p>\n<\/li>\n

              • \n

                Eye Contact:<\/strong>\u00a0Rinse with water for 15 minutes, seek medical advice.<\/p>\n<\/li>\n

              • \n

                Ingestion:<\/strong>\u00a0Rinse mouth, seek medical attention.<\/p>\n<\/li>\n<\/ul>\n

                Storage and Disposal<\/strong><\/h2>\n
                  \n
                • \n

                  Store in a tightly sealed container at 2\u20138\u00b0C, dry, away from light and incompatible materials.<\/p>\n<\/li>\n

                • \n

                  Dispose of waste according to local hazardous waste regulations.<\/p>\n<\/li>\n<\/ul>\n

                  Comparison: 4-(2-Methylpropoxy)benzenemethanamine Hydrochloride vs. Related Compounds<\/strong><\/h2>\n
                  \n
                  \n\n\n\n\n\n\n\n\n\n
                  Parameter<\/strong><\/th>\n4-(2-Methylpropoxy)benzenemethanamine HCl<\/strong><\/th>\n4-(2-Methylpropoxy)benzenemethanamine<\/strong><\/th>\n4-Isobutoxybenzylamine Acetate<\/strong><\/th>\n<\/tr>\n<\/thead>\n
                  Salt Form<\/td>\nHydrochloride<\/td>\nFree base<\/td>\nAcetate<\/td>\n<\/tr>\n
                  Solubility (Water)<\/td>\nHigh<\/td>\nModerate<\/td>\nHigh<\/td>\n<\/tr>\n
                  Stability<\/td>\nExcellent (as salt)<\/td>\nLower (amine can oxidize)<\/td>\nGood<\/td>\n<\/tr>\n
                  Use in Pharma<\/td>\nPreferred for APIs\/intermediates<\/td>\nUsed for further derivatization<\/td>\nUsed for specialty synthesis<\/td>\n<\/tr>\n
                  CAS Number<\/td>\n37806-44-3<\/td>\n4734-09-2<\/td>\n955997-89-4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
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                  How to Buy 4-(2-Methylpropoxy)benzenemethanamine Hydrochloride Online at chemikalstore.com<\/strong><\/h2>\n
                    \n
                  1. \n

                    Go online to chemikalstore.com and enter the name of the product 4-(2-methylpropoxy)benzenemethanamine hydrochloride.<\/p>\n<\/li>\n

                  2. \n

                    Check product specifications:\u00a0Purity, lot size, records and cost.<\/p>\n<\/li>\n

                  3. \n

                    Order or ask online:\u00a0Custom or bulk pricing needs to be done using the enquiry form.<\/p>\n<\/li>\n

                  4. \n

                    Protected checkout:\u00a0Various payment systems, GST invoicing and shipment tracking.<\/p>\n<\/li>\n

                  5. \n

                    Take COA and MSDS: With each batch to ensure compliance and quality assurance to the regulations.<\/p>\n<\/li>\n<\/ol>\n

                    Frequently Asked Questions (FAQ)<\/strong><\/p>\n

                    Q1: What is the main use of 4-(2-methylpropoxy)benzenemethanamine hydrochloride?<\/strong>
                    \nA: It is one of the first intermediates of the synthesis of pimavanserin, which is an antipsychotic medication, as well as in the CNS drug studies and high-performance organic synthesis.<\/p>\n

                    Q2: What is the shelf life and storage condition?<\/strong>
                    \nA: Store at 2\u20138\u00b0C in a tightly sealed container. Shelf life is typically 24 months when stored properly.<\/p>\n

                    Q3: Is this compound suitable for pharmaceutical manufacturing?<\/strong>
                    \nA: Yes, provided it meets \u226598% purity and is accompanied by COA and MSDS for regulatory compliance.<\/p>\n

                    Q4: Can I get custom or bulk packaging?<\/strong>
                    \nA: Yes, chemikalstore.com offers custom and bulk packaging for research, pilot, and industrial needs.<\/p>\n

                    Q5: What documentation is provided?<\/strong>
                    \nA: Each batch will be accompanied with a COA, MSDS and analytical data (HPLC, NMR) as a quality and regulatory assurance.<\/p>\n

                    Q6: Is this product available for export?<\/strong>
                    \nA: Yes, there is international shipping provided with all the necessary papers.<\/p>\n

                    Global Market and Supplier Insights<\/strong><\/h2>\n
                      \n
                    • \n

                      chemikalstore.com<\/strong>\u00a0\u2013 India-wide and international supply, bulk and lab packs, technical support.<\/p>\n<\/li>\n

                    • \n

                      Other global suppliers:<\/strong>\u00a0Sigma-Aldrich, TCI, Fisher Scientific, LGC Standards, CanbiPharm, Chemball<\/p>\n<\/li>\n

                    • \n

                      Price Range:<\/strong>\u00a0$100\u2013$500 per 10g\u2013100g, depending on purity and quantity.<\/p>\n<\/li>\n

                    • \n

                      Regulatory Note:<\/strong>\u00a0For R&D use only; not for human consumption or drug formulation without further processing and regulatory approvals.<\/p>\n<\/li>\n<\/ul>\n

                      Summary Table: 4-(2-Methylpropoxy)benzenemethanamine Hydrochloride<\/strong><\/h2>\n
                      \n
                      \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
                      Parameter<\/strong><\/th>\nValue<\/strong><\/th>\n<\/tr>\n<\/thead>\n
                      CAS Number<\/td>\n37806-44-3<\/td>\n<\/tr>\n
                      Synonyms<\/td>\n(4-isobutoxyphenyl)methanamine hydrochloride<\/td>\n<\/tr>\n
                      Molecular Formula<\/td>\nC\u2081\u2081H\u2081\u2087NO\u00b7HCl<\/td>\n<\/tr>\n
                      Molecular Weight<\/td>\n215.72 g\/mol<\/td>\n<\/tr>\n
                      Appearance<\/td>\nWhite to off-white crystalline solid<\/td>\n<\/tr>\n
                      Purity<\/td>\n\u226598% (HPLC\/GC)<\/td>\n<\/tr>\n
                      Melting Point<\/td>\n170\u2013175\u00b0C<\/td>\n<\/tr>\n
                      Solubility<\/td>\nWater, DMSO, methanol<\/td>\n<\/tr>\n
                      Packaging<\/td>\n1g\u20131kg bottles, custom on request<\/td>\n<\/tr>\n
                      Documentation<\/td>\nCOA, MSDS, HPLC\/NMR<\/td>\n<\/tr>\n
                      Supplier<\/td>\nchemikalstore.com (India)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
                      \n
                      \n
                      <\/div>\n
                      For bulk orders, technical queries, or customized pricing, contact our support team at chemikalstore.com.<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
                        \n
                      • \n

                        High-purity pharmaceutical intermediate for CNS drug synthesis<\/p>\n<\/li>\n

                      • \n

                        \u226598% purity, COA, MSDS, and full batch traceability<\/p>\n<\/li>\n

                      • \n

                        Bulk and laboratory packaging, prompt India-wide delivery<\/p>\n<\/li>\n

                      • \n

                        Expert technical support from chemikalstore.com<\/p>\n<\/li>\n<\/ul>\n","protected":false},"featured_media":1890,"comment_status":"open","ping_status":"closed","template":"","meta":{"_bst_post_transparent":"default","_bst_post_title":"","_bst_post_layout":"default","_bst_post_sidebar_id":"","_bst_post_content_style":"default","_bst_post_vertical_padding":"default","_bst_post_feature":"","_bst_post_feature_position":"","_bst_post_header":false,"_bst_post_footer":false},"product_brand":[],"product_cat":[85,232,171],"product_tag":[231,224,223],"product_brands":[],"class_list":{"0":"post-1843","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-more-chemicals","7":"product_cat-4-2-methylpropoxybenzenemethanamine-hydrochloride","8":"product_cat-fine-chemicals","9":"product_tag-4-2-methylpropoxybenzenemethanamine-hydrochloride","10":"product_tag-fine-chemicals","11":"product_tag-more-chemicals","13":"first","14":"instock","15":"featured","16":"shipping-taxable","17":"product-type-simple","18":"entry","19":"content-bg","20":"loop-entry"},"_links":{"self":[{"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/product\/1843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/comments?post=1843"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/media\/1890"}],"wp:attachment":[{"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/media?parent=1843"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=1843"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=1843"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=1843"},{"taxonomy":"product_brands","embeddable":true,"href":"https:\/\/chemikalstore.com\/index.php\/wp-json\/wp\/v2\/product_brands?post=1843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}